Fibrin polymerization visualized across 2mm field of view that highlights different clotting times in the different imaged areas. Plots show temporal evolution of the structural parameters being extracted with our approach.
Our lab developed a framework to track fibrin fibers as they form in plasma clot and to assess the fibrin network integrity based on single-fiber scale structural properties. By enabling rapid imaging from ultra-wide field of view, our spectrally encoded confocal microscope (SECM)-based approach can decompose the heterogenous structure of the fibrin mesh, and expand our understanding of the mechanism that transforms fibrinogen to fibrin fibers.
